Although depression is the most common psychiatric comorbidity in PD
[43], it is often underdiagnosed or undertreated [44]
43 Lemke MR, Fuchs G, Gemende I, et al. Depression
and Parkinson's disease. J Neurol. 2004;251 Suppl
6:VI/24-7.
44 Jasinska-Myga B, Putzke JD, Wider C, et al. Depres-
sion in Parkinson's disease. Can J Neurol Sci.
2010;37:61–6.
The prevalence of depression in PD varies between 20 % and 40 % of PD
patients [49, 50]
Richard IH, McDermott MP, Kurlan R, et al. A ran-
domized, double-blind, placebo-controlled trial of
antidepressants in Parkinson disease. Neurology.
2012;78:1229–36.
The largest randomized controlled study in PD assessed the
efficacy of paroxetine and venlafaxine in PD. Both drugs
were superior to placebo in treating depression, but failed to
alleviate symptoms of anxiety.
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