Showing posts with label cancer. Show all posts
Showing posts with label cancer. Show all posts

Friday, May 25, 2018

Blind women lend a hand for early detection of breast cancer

reposted from
http://cancerworld.net/news/blind-women-lend-a-hand-for-early-detection-of-breast-cancer/


Blind women lend a hand for early detection of breast cancer

VASILIKI MICHOPOULOU

The enhanced tactile sensitivity of blind and visually impaired women might make them especially suitable for breast examination, according to a visionary German gynaecologist. If it’s true that mammography is an effective breast cancer screening method until now, it’s costly and often not available for free, especially in low income level countries with a low level of health infrastructure.
(From the website http://www.discovering-hands.de)
That’s why Frank Hoffmann first thought in 2006 of training blind and visually impaired people to work in breast cancer prevention, taking advantage of their highly developed aesthetic capabilities. The German resident gynecologist from Mülheim an der Ruhr launched in 2010 a social enterprise named “Discovering hands” with the added goal of creating a new field of employment for blind and visually impaired people, by turning their disability into a special skill.
His “Medical Tactile Examiners” (MTEs) are trained for nine months to carry out physical breast examinations in medical practices and to use a standard diagnostic method for examining the female breast based on custom-developed Braille orientation strips for the detection. The MTEs never diagnose directly: they assist the doctors by lending them their “discovering hands”.
Usually, a breast examination performed by a gynecologist takes a few minutes. A tactile examiner spends at least 30 minutes for each session, not only by looking at the breast but also by educating patients about how to deal with the risk of breast cancer. Preliminary results of a still-unpublished small trial carried on at the University of Erlangen (under the supervision of Professor Matthias Beckmann) indicate that MTEs detect significantly more chest tissue changes than doctors, also because they notice them when they are smaller.
Currently, more than 35 gynecological practices and hospitals across germany employ MTEs trained by the programme; more than 12.000 examinations have been carried out to date. According to “Discovering hands”, the model has expanded in Austria, runs pilot projects in both India and Colombia while more than 25 organizations from different countries have shown interest in it.

Wednesday, March 29, 2017

Cancer Drug That Might Slow Parkinson's, Alzheimer's Headed For Bigger Tests

reposted from NPR

Cancer Drug That Might Slow Parkinson's, Alzheimer's Headed For Bigger Tests



A colored magnetic resonance imaging (MRI) scans of the brain of a 76-year-old patient with dementia shows the brain has atrophied and the dark brown fluid-filled spaces have become enlarged.
Zephyr/Science Source
Scientists are hoping that a single drug can treat two devastating brain diseases: Parkinson's and Alzheimer's.
The drug is nilotinib, which is approved to treat a form of leukemia.
In late 2015, researchers at Georgetown University Medical Center found that small doses of the drug appeared to help a handful of people with Parkinson's disease and a related form of dementia. They'd tried the unlikely treatment because they knew nilotinib triggered cells to get rid of faulty components — including the ones associated with several brain diseases.
Results of that preliminary study generated a lot of excitement because there is currently no treatment that can slow or halt the brain damage caused by either Parkinson's or Alzheimer's.
"Our phones were basically (ringing) off the hook," says Fernando Pagan, medical director of the translational neurotherapeutics program at Georgetown.
Many researchers were cautious, though. "It was such a small trial, there was no placebo control and it really wasn't designed to assess efficacy," says J. Paul Taylor, chair of the cell and molecular biology department at St. Jude Children's Research Hospital in Memphis.
So Georgetown is launching two larger and more rigorous trials of nilotinib, both designed with input from the Food and Drug Administration. One of the trials will enroll 75 patients with Parkinson's disease, the other will enroll 42 patients with Alzheimer's.
"This is going to help us identify what might have been a placebo effect and what is truly the effect of the medication," Pagan says.
Nilotinib seems to work by eliminating toxic proteins that build up in the brains of people with Parkinson's and Alzheimer's. The drug activates a mechanism in brain cells that acts like a sort of garbage disposal, Pagan says.
"Our drug goes into the cells to turn on that garbage disposal mechanism," Pagan says. "And if we're able to degrade these proteins, we could potentially stop the progression of this disorder."
The primary goal of the studies is to learn whether this powerful cancer drug is safe enough for patients with brain diseases. But the new studies should also provide better evidence about whether the drug really works.
That possibility attracts patients like Jonathan Lessin, a former anesthesiologist in the Washington D.C. area. Lessin was diagnosed with Parkinson's 14 years ago, when he was just 38.
Parkinson's gradually kills off brain cells that control movement. And for a decade after his diagnosis, drugs and a treatment called deep brain stimulation allowed Lessin to continue working. He retired several years ago, when his symptoms progressed to the point that he feared he might not be able to provide first-rate care for his patients.
Since then, the disease has caused Lessin's speech to become slightly slurred. "It's slowly progressing," he says. "My balance is getting worse and worse. I'm falling more and more during the day. But I'm still able to do things like rock climb and ski and bike."
Lessin has been able to stay active thanks to treatments that help control symptoms. But the disease continues to eat away areas of his brain.
So Lessin was excited to learn about the Georgetown study, which held the tantalizing prospect of a drug that just might slow or halt that process.
"I've always been riding the leading edge of treatment," Lessin says. "And I just figured I'd go for it."
As a former physician, Lessin fully understands the limitations of the earlier trial, and the risks of taking a powerful cancer drug. But as someone with Parkinson's, he sees an opportunity.
"I'm very optimistic," he says. "I've seen it cure Parkinson's in mice. I've seen people who can talk again, walk again, which is very encouraging."
There's good reason for patients with Parkinson's, Alzheimer's and other neurodegenerative diseases to be optimistic these days, Taylor says.
Drugs like nilotinib are coming along because years of research have provided a much better understanding of how these damage the brain, he says. "Now we're in the payoff phase."
Taylor still isn't sure whether nilotinib will live up to its early promise. But, he says, "If the results of this trial don't turn out to be as exciting as the very tiny trial suggested, I would not get too pessimistic because there are other developments that are in the wings."
The Georgetown studies are enrolling patients now and will take more than a year to complete.
Information about the Parkinson's study can be found here. Information about the Alzheimer's study is available here.

Thursday, July 7, 2016

Tango Therapy May Cut Risk Of Falls In Cancer Patients

reposted from
http://www.ndtv.com/health/tango-therapy-may-cut-risk-of-falls-in-cancer-patients-1428662


Tango Therapy May Cut Risk Of Falls In Cancer Patients

Tango Therapy May Cut Risk Of Falls In Cancer Patients
The findings revealed that after just five weeks of tango, cancer survivors could regain some amount of balance. (Representational Photo)
NEW YORK:  Argentine Tango dance has the potential to significantly improve balance and reduce falls risk among cancer patients post treatment, finds a study that addresses the prevalent side effects of cancer treatment.

According to researchers nearly 70 per cent of cancer patients treated with chemotherapy will experience peripheral neuropathy as a side effect post treatment. 

Peripheral neuropathy is weakness, numbness or loss of sensation in the hands, fingers, feet and toes and pain from nerve damage. 

The findings revealed that after just five weeks of Argentine tango, medial and lateral sway decreased by 56 per cent indicating that this is a promising balance intervention for cancer survivors experiencing impaired balance post treatment.

"The study showed that Argentine Tango has measurable effects on balance -- but our patients report really enjoying dance as therapy. It is a fun, social way to do the necessary work and our initial data shows it has some positive impact for restoring balance," said Mimi Lamantia from The Ohio State University in the US.

In addition, the patients also found that the Argentine tango was more easier to adhere than the traditional physical therapy. 

"So many patients tell us that it is difficult to stay committed to physical therapy because it is hard and feels like work," Lamantia added.

Long-term neuropathy in the feet and toes can be especially problematic because it affects a person's balance and gait. This puts them in an elevated fall risk when they are engaging in daily life activities.

"That's a big deal because many more people are surviving cancer. Dealing with the issues that impact a person's quality of life after cancer is extremely important," noted another researcher Lise Worthen-Chaudhari from The Ohio State University.

For the study, the team designed a dance intervention course that involved 20 sessions of adapted Argentine Tango. Patients participated in one-hour sessions twice a week for 10 weeks.

Researchers measured patients' standing postural sway (eyes closed) with a computer-aided force platform at the beginning of the dance intervention series and at completion of the 10-weeks of instruction. Patients were also asked to report satisfaction with the intervention.

Initial data from the first three patients who participated in the Argentine Tango study will be presented at the 2016 annual meeting of American Congress of Rehabilitation Medicine in Chicago.
 

(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)

Wednesday, February 11, 2015

Make way for Melanie Adrian

reposted from


Make way for Melanie Adrian

From innovative teaching to human rights to breast cancer treatment reform, this Carleton professor is relentless in her pursuit for change.
By MOIRA MACDONALD | February 11, 2015
The assignment: Multiculturalism and republicanism – draw and contrast.
It’s a puzzle Melanie Adrian’s students at Carleton University are mulling over in small groups shortly after 5 p.m. on an already dark, mid-fall afternoon. It could be classic snooze-button time for any student grinding through the final hour of a three-hour lecture at the back end of term. Not here. The room is full of chatter. Nobody looks quite sure what they’re doing, yet there are smiles, laughter, debates, and pencils scribbling on handouts featuring two differently sized circles, several arrows and stick-people – suggestions only, to prime students’ creative and intellectual pumps.
Dr. Adrian, a law and legal studies professor, moves from one group to another, leaning over to size up what each has so far. She isn’t totally sure this exercise is going to work either. And she’s running out of time for today.
“I’ve seen some fabulous diagrams,” she says, advising students to bring their drawings to a subsequent class so they can carry on the discussion. “Please think about it over the next two weeks. There’s no right or wrong here. We’re contrasting them. They’re experiments.”
Experimenting and taking risks are natural territory for Dr. Adrian. That’s probably not a bad thing for a surfing enthusiast who rides the waves off the Californian and Mexican Pacific coast whenever possible and who teaches and writes about the often touchy intersection between religion and human rights. Today’s class – about limitations and restrictions on people’s freedom of belief – includes a discussion about students’ experience of the fatal Oct. 22 shooting attack in Ottawa and its connections to Islam that were later presented in the media.
Since Dr. Adrian started teaching at Carleton in 2010, she has brought in local slam poets and used hip hop music from the Middle East and Africa to help students connect more deeply with such fundamental human-rights legal concepts as democracy and freedom. Last year the pre-tenured professor raised eyebrows by allowing students taking her third-year international human rights law course to spend the first three weeks deciding what they would learn and how they would be assessed. The United Nations-style setting was intended to get students grappling with the fundamental practices they would be studying: negotiation, agreement and the application of democratic principles. Students commented at the end of term that being put in the driver’s seat of their own learning pushed them to ask more questions, find out what really interested them and fully engage with the topic.
Whatever her interests, law professor Melanie Adrian pursues it all with a trail-blazing passion. Photo by Scott Adamson.
Whatever her interests, law professor Melanie Adrian pursues it all with a trail-blazing passion. Photos by Scott Adamson.
“Melanie is a really great example of what happens when you take student voices seriously,” says Samah Sabra, a coordinator in Carleton’s Educational Development Centre who is researching the pedagogical outcomes of Dr. Adrian’s third-year course.
“Relentlessly innovative,” adds her law department colleague Vincent Kazmierski. “She’s an incredibly passionate person and she brings that passion to her teaching.”
Dr. Adrian’s student-centered style earned her a Carleton University New Faculty Excellence in Teaching Award in 2014. At year end, she learned she’d won one of the five distinguished Teaching Achievement Awards that the university bestows annually.
For former student Carla Carbajal, who took Dr. Adrian’s first-year law course four years ago, the assignment to present a hip hop song allowed her to connect her past – she had emigrated as a teenager from a dangerous neighbourhood in El Salvador – to her studies in Canada where she was still struggling to find her place. For a course project, she returned to El Salvador to do research in a school for children with intellectual disabilities and interview government officials about laws regarding child protection. Dr. Adrian even helped her organize an in-class bake sale to raise money for the school. Ms. Carbajal went far beyond what was needed for a first-year course, but her classroom experience had lit a fire: “I told other students, ‘Make sure you take a class with Dr. Melanie Adrian, because she will change your life and she will show you what university should be like.’”
A deliberate and creative approach to constructing meaningful learning – her own and others’ – has been standard practice for Dr. Adrian throughout her academic career. She also has a gift for persuading others to make allowances for the new trail she may need to blaze to get there – a friend says she could sell a used tea bag if required. Her warm, energetic personality, genuine interest in people and knack for making contacts haven’t hurt either.
Dr. Adrian embarked on her first ethnographic study during an under-graduate co-op term with an Asian human rights organization in 1995, when she interviewed people on the margins of Hong Kong society. She had no idea that that was what she was doing – “I just really wanted to go and talk to people and get to know their stories and write them down” – but she nevertheless convinced a professor at the University of Waterloo to accept the work for credit, and presented it to interested faculty and students when she got back.
“I charted out a very different course,” she says about her first degree in religious studies with a minor in peace and conflict. It was where she began developing an academic interest in Islam (she has no religious affiliation herself). The degree program was something she used to “get to know areas of the world I didn’t know. … I got an idea, then I convinced the administration to let me do it as a co-op term.”
Her persuasiveness and focus on exactly what she wanted to learn carried into her doctoral work at Harvard University in religious studies and human rights. Unable to find any one department that was able to supervise the work she wanted to do, she crafted her own interdisciplinary doctorate straddling religion and anthropology.
“It takes a lot of courage to do that. … She was the only student I have worked with who put together her own PhD program,” says Kimberly Theidon, a medical anthropologist who supervised Dr. Adrian at Harvard (she’s currently a fellow at the Woodrow Wilson International Center in Washington, D.C. and associate research professor at Tufts University). She credits her student for being “willing to follow the questions to where they take her.”
The doctoral candidate began by researching Muslims in Peru but switched focus to the divisive controversy unfolding in France over the display of religious symbols in schools, including a ban against Muslim girls wearing head scarves. She wanted to find out what the state’s position would mean for young Muslim women. “I just didn’t understand why they would go that far,” she says about the recommendations from France’s Stasi Commission in late 2003.
A commission member helped her arrange a one-year English teaching position at a high school in a Paris suburb and get clearance for the deep access she felt she needed. She soon found such banlieues had residents who were second- and third-generation French citizens yet were so isolated that they struggled to be accepted as French by those outside. Even the school she worked and lived in was divided: it had an academic program that educated mostly white middle- and upper-class students bussed in from outside the neighbourhood and a more volatile trades program filled with students of immigrant backgrounds from the immediate neighbourhood who lived with poverty, crime and violence.
Then the riots of October and November 2005 broke out. Some 250 cars were burned in the school’s vicinity. By day, Dr. Adrian would teach and learn from her students. But on several nights, some returned to help firebomb the school and staff residences, where she lived, targeted as a state symbol. Their English teacher helped put the fires out, but she spent many a night lying awake wondering if she’d be burned alive in her bed. She realized that she was caught up in a conflict too big to be personal.
She turned it into a teachable moment. In her trades classes she would hold up a newspaper clipping about the events from the night before and simply ask, “Why?” With her more privileged students, she would write provocative statements on the blackboard, such as “France is racist,” and let an animated discussion ensue, something she says could only happen because an atmosphere of mutual respect and trust had already been established. Students were practising their English, certainly, but their teacher also gained a window into their worlds and opinions. She used hip hop music for the first time as another conversational springboard.
What she learned forms part of her first book, Risking Religious Freedom: France, Muslims and the Right to Act on Faith, expected to be published in the fall of 2015. Among the insights she came away with was “a very deep appreciation of how local and domestic concerns can shape and create policy that either is or isn’t in conformity with human rights norms.”
While she understands France’s reasons for banning the hijab in schools, she doesn’t believe it’s a good policy and worries this and other similar policies are putting liberalism at risk: “If the state can tell you what you can put on your head, what else can it tell you?”
Negotiating space for cultural difference was something Dr. Adrian learned at a young age. She grew up with three sisters in a German-Canadian household in Waterloo, Ontario, that more often than not put up visiting students from all over the world. Over a 15-year period the family hosted more than 30 students who stayed from six months to a year.
As well, her parents had “a really strong focus on justice. It was part of my daily life from the time I can remember.” Her late father, Werner, was a respected optometry professor and inventor at the University of Waterloo. Her mother, Elisabeth, was a role model for openness and community involvement, someone who rolled up her sleeves and helped when she saw someone or something that needed attention.
“We talked about the world, but the world was at our table,” says Dr. Adrian. Such an experience, she says, “creates a very specific type of environment that is outward-looking, receptive to culture and ideas, that forces you to negotiate your identity all the time. … I have sisters and brothers around the world because of that.” As a high-school student, she travelled on international exchanges, becoming fluent in Spanish and French.
Her pedagogical ideas really started to germinate when she became a Harvard lecturer after finishing her PhD in 2007. During those “three wonderful years,” she experimented with variations on flipped classrooms and field trips to religious sites, even art galleries, to help students connect what was being discussed in the classroom to how it played out in the world beyond Harvard.
Her legal orientation had come from her master’s program under the direction of the late Kevin Boyle, a human rights lawyer and activist at the University of Essex. Once she arrived on campus in 1998, she learned that the star attraction that had drawn her to Essex in the first place was on sabbatical. She negotiated her way into doing research for Dr. Boyle during his break and he helped pave her way by bringing her along on his speaking engagements – one to the British parliament on interreligious dialogue – and promoted her CV to academics in the field once she announced her intention to pursue a doctorate. She believes that supporting students in that way is “the kind of thing we in academia have to do.”
The concept of risk took on a very personal dimension in early 2011. Just months into her first tenure-track position at Carleton and weeks after returning from another surfing vacation, she was diagnosed with invasive breast cancer. Amid the shock and horror of the news was also disbelief that the only treatment she was offered was a classic mastectomy with reconstruction to follow later. At just 37 and with all the attention breast cancer had been receiving, she could not accept that that was her only option.
“It just seemed so barbaric to me that we have been running, walking, jumping, flying, biking for the cure … and the only thing that these surgeons can tell me is that ‘You’ve gotta cut it off?’ It just didn’t compute to me,” she says.
Within a couple of weeks she had worked her international contacts and learned that she was a good candidate for another procedure. A skin- sparing mastectomy removes all but the breast’s skin envelope, and the breast is rebuilt right then. The challenge was finding someone who could do it in Canada – fast. Meanwhile, she was finishing the winter term at Carleton, teaching an online course through Harvard, and consulting for UNICEF on an evaluation of its development programs in the context of international human rights law.
feature_melanieadrian_644_2
The call that she had an appointment with Nicole Hodgson, a surgeon performing the skin-sparing procedure at Hamilton’s Juravinski Cancer Centre, came while she was in Senegal in early May for UNICEF. She had less than two days to make it to the Hamilton clinic.
“Our administrative assistant had to sell her first child to Air France to get me a seat from Dhakar to Toronto,” she jokes. Before the end of the month she’d had the operation, revealing that her cancer was advanced. That required a full suite of follow-up treatments – aggressive chemo-therapy and radiation, with their own side effects and life-altering considerations, things that Dr. Adrian believes can be too easily glossed over by doctors intent on saving patients’ lives.
An anthropologist, she talked to other cancer patients and found the systemic pitfalls she’d dealt with were common, and that “really, really bothered me.” As a human rights champion, she decided to do something about it.
She sought out senior administrators from the Ottawa Hospital and started talking to them about why she’d had the experience she’d had and what could be done to give breast cancer patients equal and hassle-free access to all the information and treatments available. They were receptive, although the hospital says it was already moving along the same lines. “I see the change,” she says, crediting those in charge for hiring surgeons who could offer expanded treatment options. A hospital expansion will consolidate all its breast cancer specialists and services into one hub.
However, the true shift, she realized, had to happen among patients so that they could take an equal seat at the table of their own treatment. So, with lots of help from friends, former students, cancer survivors and specialists, she founded Be the Choice, a not-for-profit organization whose goal is to give breast cancer patients the knowledge and language they need to make more informed choices about their care. Its key project is the development of a multilingual, online decision tree that takes the user step by step through the questions they need to consider and ask, and options that can be available, depending on the patient’s type of cancer and stage of life.
“This is not about removing the doctor at all,” says Dr. Adrian, whose group has consulted heavily with expert physicians during the tool’s development. “This is about empowering, informing, so patients have a more interesting conversation with their doctor.”
Throwing herself into such an intensive project while still recovering from cancer treatment herself does not surprise those who know her. Her mother, also a breast cancer survivor, says her daughter is someone “who goes as far as she can get. She’s not afraid.”
“It’s a testament to her passion,” says Robin Beasley, a Carleton colleague who was diagnosed with breast cancer at age 40, shortly after Dr. Adrian, and who co-founded Be the Choice with her. “Her vision is making change for women in Ottawa and across the country. It’s about making things accessible.”
With Be the Choice’s decision-making tool nearly ready to launch (bethechoice.org), Dr. Adrian climbed back onto her beloved surfboard and the Pacific Ocean’s waves this winter while finishing her book. But before she left, she was making plans to take her students “to a whole new pedagogical zone” when she’s back in Ottawa this summer. In her summer course on social justice and human rights, she wants to incorporate student interviews with high-profile “justice makers” and members of the Ottawa community, to encourage students to think deeply about what it takes to be an ethical decision-maker.
She explains, “I don’t just teach for knowledge’s sake. I teach so I can hopefully spark a passion or an interest in the students. If the students leave with the idea that their critical thinking is necessary and useful and that they can contribute by engaging in that kind of thought, then I feel that I’ve done my job.”