The olfactory bulb volume in patients with idiopathic Parkinson's disease

reposted from

Friday, 1 May 2015

The olfactory bulb volume in patients with idiopathic Parkinson's disease

How disappointing... this is something I have been thinking and talking to others about for some time... sadly it hasn't show anything suggestive. 

Eur J Neurol. 2015 Apr 23. doi: 10.1111/ene.12709. [Epub ahead of print]

Paschen L, Schmidt N, Wolff S, Cnyrim C, van Eimeren T, Zeuner KE, Deuschl G, Witt K.

BACKGROUND AND PURPOSE:

This study addresses the question of whether the neuropathological findings on the olfactory bulb (OB) in idiopathic Parkinson's disease (IPD) correspond to a detectable change in volume of the OB. Additionally, the relationship between OB volume and residual olfactory function, clinical disease characteristics and age are investigated.

METHODS:

Fifty-two IPD patients were investigated and compared to 31 healthy age-matched controls. All participants were scanned using a 3 T magnetic resonance imaging MRI scanner including a T2 DRIVE sequence in coronal slices through the OB. The OB volumes were measured via manual segmentation of the OB. Olfactory testing was carried out using the Sniffin' Sticks test battery.

RESULTS:

The OB volume in the IPD group was 42.1 mm³ (SD ± 11.6) for the right and 41.5 mm³ (SD ± 11.7) for the left OB and showed no difference from the controls. Additionally, there were no significant correlations between OB volume and disease characteristics such as disease duration or Unified Parkinson's Disease Rating Scale motor score. Likewise, patients' residual smell function did not correlate with their OB volume. In contrast, controls indicated a correlation between smell function and OB volume.

CONCLUSION:

The study shows that high resolution MRI does not show a detectable volume loss of the OB in PD patients. It is concluded that OB measurement using in vivo high resolution MRI at 3 T is not helpful to identify IPD.

reposted from
http://www.eurekalert.org/pub_releases/2013-11/nrr-vmr110313.php

PUBLIC RELEASE DATE:

3-Nov-2013

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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research 

Voxel-based magnetic resonance morphometry in Parkinson's disease patients

		IMAGE: This is a three-dimensional coronal image in MNI standard coordinate of statistical analysis results using pseudo-color. The pseudo-color represents atrophic brain areas in the patient group. Click here for more information.

Non-motor symptoms, including abnormalities in cognition, mental behaviors, autonomic nerves and sensory perception, have the greatest effect on the quality of in Parkinson's disease patient life. Voxel-based morphometry can be used to quantitatively compare structural differences and functional changes of gray matter in subjects. According to a study, Gray matter images of 32 Parkinson's disease patients and 25 healthy controls were compared using voxel-based morphometry to investigate the correlation between brain structural loss and non-motor symptoms in Parkinson's disease. Comparison of gray matter images showed that gray matter volume was significantly diminished in patients with Parkinson's disease compared with normal controls, including the bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of cerebellum. These findings, published in the Neural Regeneration Research (Vol. 8, No. 27, 2013), indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson's disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson's disease.

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Article: " Magnetic resonance morphometry of the loss of gray matter volume in Parkinson's disease patients," by Jianguo Xia1, Juan Wang2, Weizhong Tian1, Hongbin Ding1, Qilin Wei3, Huanxin Huang3, Jun Wang3, Jinli Zhao4, Hongmei Gu4, Lemin Tang2 (1 Department of Radiology, Taizhou People's Hospital of Nantong University, Nantong 225300, Jiangsu Province, China; 2 Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China; 3 Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China; 4 Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China)

Xia JG, Wang J, Tian WZ, Ding HB, Wei QL, Huang HX, Wang J, Zhao JL, Gu HM, Tang LM. Magnetic resonance morphometry of the loss of gray matter volume in Parkinson's disease patients. Neural Regen Res. 2013;8(27):2557-2565.

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/

Full text:http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=729

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