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Blocking a single neurotransmitter in the brain may stop the firing of the nerves that are linked with migraine headaches, a newstudy
in animals suggests.
In experiments, researchers looked at the effects of two vasodilators — which aremedicines that cause blood vessels to widen, increasing blood flow — on certain receptors in rats' brain cells.
They found that when they administered one of these vasodilators, nicknamed PACAP, directly into the rats' brains, a cluster of neurons in the center of the head called the trigeminovascular system started firing more than normal, mimicking the symptoms of a migraine in the animals. The researchers measured this firing by using electrodes to monitor signals from the rats' brains.
Migraines May Begin Deep in the Brain
by Jesse Emspak, Live Science Contributor | October 08, 2015 04:02am ET
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 Credit: Headache photo via Shutterstock
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in animals suggests.In experiments, researchers looked at the effects of two vasodilators — which aremedicines
that cause blood vessels to widen, increasing blood flow — on certain receptors in rats' brain cells.They found that when they administered one of these vasodilators, nicknamed PACAP, directly into the rats' brains, a cluster of neurons in the center of the head called the trigeminovascular system started firing more than normal, mimicking the symptoms of a migraine in the animals. The researchers measured this firing by using electrodes to monitor signals from the rats' brains.
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