Showing posts with label corollary discharge. Show all posts
Showing posts with label corollary discharge. Show all posts

Wednesday, August 10, 2016

A lot of "voice hearing" isn't an auditory experience at all

reposted from BPS


A lot of "voice hearing" isn't an auditory experience at all

The message from recent surveys is that it's not just people with a diagnosis of schizophrenia who hear voices in their heads, many people considered mentally well do to. This revelation may have a welcome de-stigmatising effect in terms of how people think about some of the symptoms associated with a diagnosis of schizophrenia, but a new study published in Psychosis asks us to hang on a minute – to say that one "hears voices" can mean different things to different people. You might assume that "hears voices" means that a person has an hallucinated auditory experience just like someone is talking to them. But what about hearing an inner voice that is experienced like an out-of-control thought rather than an external voice? Or a heard voice that's not like either a thought or an external voice?

Our knowledge of the experience of voice hearing among patients has been limited by the fact that a lot of psychiatric research in this area (though not all) has been categorical in nature. For instance, a typical psychiatric scale used in research or the clinic includes a vague item like "[Patient] Reports voices than no one else hears" and a tick here can conceal a huge range of different experiences.

For the new research, Nev Jones and Tanya Luhrmann conducted in-depth interviews with 80 people diagnosed with schizophrenia in the US, India and Ghana about their first-hand experiences of hearing voices. There was great variety between participants in their descriptions of voice hearing and also within each individual participant's own descriptions. Perhaps most importantly, while 79 per cent of the participants reported at least some limited experience of the hallucinated sound of external voices – as if someone was audibly speaking to them – a much smaller proportion (17.5 per cent) said this was theirdominant experience of "voice hearing".

The most common dominant experience for the participants was to say they had a mixture of auditory and thought-like voices – 29 per cent reported having this. Another 15 per cent said their dominant experience was to hear thought-like voices that seemed "foreign and alien" but clearly "non-auditory". Other categories were "in-between", being neither auditory or thought-like; "limited auditory" (an auditory experience but just simple words or sounds); "transformed", which is when real voices or sounds were misheard as saying something different; and "multi-sensory", involving visual experiences as much as or more than auditory – for example, one participant described how "the voice will show me all my enemies".

Intriguingly, some participants described how a voice could begin as thought-like, but if they ignored it, then it became more auditory: "If I try ignoring them inside my brain, like they come out. They start telling me things."

The researchers said the interviews showed there is huge variety in the ways that people diagnosed with schizophrenia hear voices, and that it is very difficult for both patients and clinicians to find ways to accurately describe these experiences. Another thing – many of the participants said that what they found most difficult about "hearing voices" was the disruption to their thoughts, rather than the sensory aspect of the experience. Indeed, by emphasising the normality of the auditory aspect of hearing voices, the researchers said there was a risk of mental health professionals presenting a "misleading view of what at least some patients are in fact struggling with".

_________________________________ ResearchBlogging.org

Jones, N., & Luhrmann, T. (2016). Beyond the sensory: Findings from an in-depth analysis of the phenomenology of “auditory hallucinations” in schizophrenia Psychosis, 8 (3), 191-202 DOI:10.1080/17522439.2015.1100670

--further reading--
The voices heard by people with schizophrenia are friendlier in India and Africa, than in the US
What's it like to hear voices that aren't there?
The same voices, heard differently?
You hear a voice in your head when you're reading, right?

Post written by Christian Jarrett (@psych_writer) for the BPS Research Digest.

Friday, April 4, 2014

Noisy brain signals: How the schizophrenic brain misinterprets the world

reposted from


Noisy brain signals: How the schizophrenic brain misinterprets the world

PUBLISHED: 2 APR 2014
People with schizophrenia often misinterpret what they see and experience in the world. New research provides insight into the brain mechanisms that might be responsible for this misinterpretation. The study from the Montreal Neurological Institute and Hospital – The Neuro - at McGill University and McGill University Health Centre, reveals that certain errors in visual perception in people with schizophrenia are consistent with interference or ‘noise’ in a brain signal known as a corollary discharge.  Corollary discharges are found throughout the animal kingdom, from bugs to fish to humans, and they are thought to be crucial for monitoring one’s own actions.  The study, published in the April 2 issue of the Journal of Neuroscience, identifies a corollary discharge dysfunction in schizophrenia, which could aid with diagnosis and treatment of this difficult disorder. It was carried out in collaboration with researchers Veronica Whitford, Gillian O’Driscoll, and Debra Titone in the Department of Psychology, McGill University.
“A corollary discharge is a copy of a nervous system message that is sent to other parts of the brain, in order to make us aware that we are doing something,” said Dr. Christopher Pack, neuroscientist at The Neuro and lead investigator on the study.  “For example, if we want to move our arm, the motor area of the brain sends a signal to the muscles to produce a movement. A copy of this command, which is the corollary discharge, is sent to other regions of the brain, to inform them of the impending movement. If you were moving your arm, and you didn’t have the corollary discharge signal, you might assume that someone else was moving your arm. Similarly, if you generated a thought, and you had an impaired corollary discharge, then you might assume that someone else placed the thought in your mind. Corollary discharges ensure that different areas of the brain are communicating with each other, so that we are aware that we are moving our own arm, talking, or thinking our own thoughts.”
Schizophrenia is a disorder that interferes with the ability to think clearly and to manage emotions. People with schizophrenia often attribute their own thoughts and actions to external sources, as in the case of auditory hallucinations. Other common symptoms include delusions and disorganized thinking and speech. 
Recent research has suggested that an impaired corollary discharge can account for some of these symptoms. However, the nature of the impairment was unknown. In their study, Dr. Pack and his colleagues (including Dr. Alby Richard, neurology resident at The Neuro) used a test called a perisaccadic localization task, to investigate corollary discharge activity. In this test, subjects are asked to make quick eye movements to follow a dot on a computer screen. At the same time they are also asked to localize visual stimuli that appear briefly on the screen from time to time.  In order to perform this task accurately, subjects need to know where on the screen they are looking – in other words they use corollary discharges signals that arise from the brain structures that control the eye muscles.
The results showed that people with schizophrenia were less accurate in figuring out where they were looking. Consequently they made more mistakes in estimating the position of the stimuli that were flashed on the screen. “What is interesting and potentially clinically important is that the pattern of mistakes made by the patients correlated with the extent of their symptoms,” said Dr. Pack. ““This is particularly interesting because the circuits that control eye movements include the best-understood structures in the brain. So we are optimistic that we can work backward from the behavioral data to the biological basis of the corollary discharge effects. We have already started to do this with computational modeling. Mathematically we can convert the corollary discharge of a healthy control into the corollary discharge of a patient with schizophrenia by adding noise and randomness. It is not that people with schizophrenia have no corollary discharge, or a corollary discharge with delayed or weaker amplitude. Rather the patients appear primarily to have a noisy corollary discharge signal. This visual test is very easy thing to do and quite sensitive to individual differences. “
The study shows that patients with schizophrenia make larger errors in localizing visual stimuli compared to controls. These results could be explained by a corollary discharge signal, which also predicts patient symptom severity, suggesting a possible basis for some of the most common symptoms of schizophrenia. This work was supported by The Natural Sciences and Engineering Research Council of Canada, The Brain & Behavior Research Foundation (NARSAD) and the EJLB Foundation.
The Neuro
The Montreal Neurological Institute and Hospital — The Neuro, is a unique academic medical centre dedicated to neuroscience. Founded in 1934 by the renowned Dr. Wilder Penfield, The Neuro is recognized internationally for integrating research, compassionate patient care and advanced training, all key to advances in science and medicine. The Neuro is a research and teaching institute of McGill University and forms the basis for the Neuroscience Mission of the McGill University Health Centre.  Neuro researchers are world leaders in cellular and molecular neuroscience, brain imaging, cognitive neuroscience and the study and treatment of epilepsy, multiple sclerosis and neuromuscular disorders. For more information, visit theneuro.com.

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