CVR speaker -
http://www.rutishauserlab.org/
Talk on Memory and Attention measured in Human Brain Cells
http://www.rutishauserlab.org/
Talk on Memory and Attention measured in Human Brain Cells
where: BSB 163 - Behavioral Science Building Room 163 (York University Campus)
when: 4pm-5pm,
Thursday 19th of March
Probing the Mechanisms of Learning and Memory at the Single-Neuron Level in Humans
(Ueli Rutishauser (Assist. Prof.) Neurosurgery, Neurology & Biomedical Sciences, Cedars-Sinai Medical Center)
Summary: How neuronal circuits enable complex behaviors such as learning and decision making remains poorly understood. We take advantage of rare neurosurgical procedures to record at single-cell resolution in behaving humans. I will review our experimental studies of individual neurons in the human hippocampus and amygdala during the formation and retrieval of declarative memories. These studies provide unique mechanistic insights into the relationship between neuronal activity, plasticity, memory formation, and the role of theta in coordinating large-scale neuronal dynamics. I will describe evidence for two distinct functional types of neurons in the human medial temporal lobe: visually selective (VS) and memory selective (MS) neurons. VS neurons have highly specific sensory responses that occur early and irrespective of previous experience. MS neurons, on the other hand, are not visually selective, and are highly sensitive to previous experience and the internal brain state. Dynamically, the response of these two subpopulations is orthogonal to each other. I will further describe evidence that MS and VS neurons are anatomically distinct and that their interaction is fundamental to the formation and retrieval of memories. These two functional subpopulations are a candidate for a circuit-level description of memory formation.
Books
Fried I, Rutishauser U, Cerf M, Kreiman G, eds. Single Neuron Studies of the Human Brain — Probing Cognition. MIT Press: Boston; 2014.
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