Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair.

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Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair.

Int J Neurosci. 2014 Nov 3:1-17. [Epub ahead of print]

Vivekanantham S, Shah S, Dewji R, Dewji A, Khatri C, Ologunde R.

Abstract

Neuroinflammation in Parkinson's disease [PD] is a process that occurs alongside the loss of dopaminergic neurones, and is associated with alterations to many cell types, most notably microglia. This review examines the key evidence contributing to our understanding of the role of inflammation-mediated degeneration of the dopaminergic (DA) nigrostriatal pathway in PD. It will consider the potential role inflammation plays in tissue repair within the brain, inflammation linked gene products that are associated with sporadic parkinsonian phenotypes (alpha-synuclein, parkin and Nurr 1), and developing anti-inflammatory drug treatments in PD. With growing evidence supporting the key role of neuroinflammation in PD pathogenesis, new molecular targets are being found that could potentially prevent or delay nigrostriatal DA neurone loss. Hence, this creates the opportunity for disease modifying treatment, to currently what is an incurable disease.